In the third year of the degree, McLoughlin decided to drop out and return home to Ballycumber. McLoughlin studied music technology and production at Limerick Institute of Technology. When he was 18, McLoughlin and his family moved to a cabin in Ballycumber. He was given his nickname 'Jack Septic Eye' after a childhood accident during a football match in which he injured his eye. McLoughlin began playing video games at the age of seven and as a child he spent time playing on the Nintendo Game Boy in a neighbourhood treehouse, later describing how he found a sense of belonging in the games. His father worked for the ESB and his mother worked a number of jobs before becoming a carer for his grandmother. He was raised in Cloghan in County Offaly, Ireland and also lived for a time in Banagher.

He is primarily of Irish and British descent, and possibly with some Iberian heritage. 1936 – 27 January 2021) and Florrie McLoughlin.

Seán William McLoughlin was born on 7 February 1990, the youngest of five children to John ( c. He is also an active philanthropist, participating in multiple fundraisers that have raised tens of millions for charitable organizations, for which he has received awards from organisations such as Save the Children and Junior Chamber International. McLoughlin is a co-founder of the clothing brand Cloak with fellow YouTuber Markiplier and the founder and owner of the Top of The Mornin' Coffee company. The following year, he released a biographical documentary entitled How Did We Get Here? which featured footage from his tour of the same name. In 2021, McLoughlin appeared in the film Free Guy starring Ryan Reynolds. He continued to create YouTube videos and appear in live events, including Summer Game Fest in 2020. In 2018, he began streaming exclusive content on Twitch as part of a multi-year deal with Disney Digital Network.

Throughout 2017, McLoughlin appeared on Disney XD and Irish national television before touring in Europe and the US in 20 for his How Did We Get Here tour and the Game Grumps' Ready Player 3 tour. He started uploading videos to YouTube in December 2012 and his channel grew rapidly in the following years, reaching a million subscribers in 2014 and 10 million by 2016. Raised in Cloghan, County Offaly in Ireland, McLoughlin played videogames from a young age. As of October 2023, his YouTube channel has accumulated 16.4 billion views and over 30 million subscribers, making it the 2nd most-subscribed Irish channel on YouTube.

Much of McLoughlin's YouTube content centres around gaming and vlogs. Seán William McLoughlin ( / m ə ˈ k l ɒ x l ɪ n/ mə- KLOKH-lin born 7 February 1990), better known online as jacksepticeye, is an Irish YouTuber.

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